Parathormone promotes glycogen formation from [14C]glucose in cultured osteoblast‐like cells

[摘要]

Parathyroid hormone stimulates [U-¹⁴C]glucose incorporation into glycogen of cultured osteoblast-like calvaria cells. This effect is detectable only several hours after the addition of PTH and it is mimicked by dibutyryl cyclic AMP. In contrast to insulin (in pharmacological concentrations), PTH enhances glycogen formation only in calvaria cells, but not in fibroblasts. Insulin-like growth factor I in physiological concentrations promotes glycogen-synthesis shortly after addition.

[学科分类] 生物化学/生物物理

[关键词] Osteoblast-like cell;Glycogen synthesis;Parathyroid hormone;Cyclic AMP;Insulin-like growth factor;Insulin