Thymidine triphosphate dephosphorylating activity in regenerating rat liver

[摘要]

The enzyme activity of dephosphorylation of thymidine triphosphate was found in microsomal fraction of rat liver. The enzyme activity decreased at the time when [³H]thymidine incorporation into DNA of regenerating liver increased. When the [³H]thymidine incorporation was suppressed by 1,3-diaminopropane, the enzyme activity remained elevated. These results suggest that the enzyme activity appears to be closely linked to DNA synthesis.

[学科分类] 生物化学/生物物理

[关键词] Thymidine triphosphate;Thymidine triphosphate dephosphorylation;Regenerating liver;Cell growth;1;3-Diaminopropane;Polyamine;TTP;deoxythymidine triphosphate;TDP;deoxythymidine diphosphate;TMP;deoxythymidine monophosphate;ATPase;ATP phosphohydrolase;PPO;2;5-diphenyloxazole;POPOP;1-4-bis[2-(5-phenyloxazolyl)]-benzene;n.d;not determined