A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family
[摘要] We isolated a novel gene designated spinal cord-derived growth factor (SCDGF). Its expression was increased in chick spinal cords with embryonic development and decreased after hatching. The amino acid sequences of chick and human SCDGFs revealed a putative signal sequence followed by a CUB domain and a region homologous to the members of the platelet-derived growth factor/vascular endothelial growth factor family. Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物化学/生物物理
[关键词] Spinal cord-derived growth factor;Differential display;Chick spinal cord;Mitogenic activity;CUB domain;Platelet-derived growth factor/vascular endothelial growth factor family;SCDGF;spinal cord-derived growth factor;PDGF;platelet-derived growth factor;VEGF;vascular endothelial growth factor;E;embryonic day;TLD;tolloid;BMP1;bone morphogenetic protein 1;NP;neuropilin;5′-RACE;5′-rapid amplification of cDNA ends;EST;expression sequence tag;c;chicken;h;human;ORF;open reading frame [时效性]
