The sequences of enterohemorrhagic Escherichia coli and Yersinia pestis that are homologous to the enteroaggregative E. coli heat‐stable enterotoxin gene: cross‐species transfer in evolution
[摘要] The enteroaggregative Escherichia coli heat-stable enterotoxin 1 (EAST1) gene is widely distributed among diarrheagenic E. coli. In this study, we examined the sequences of enterohemorrhagic E. coli (EHEC) strains by PCR and sequencing. All the EHEC strains possessed the EAST1 gene homologues but with two types of mutations. One of the mutation types was strongly associated with the large outbreak episodes in 1996 in Japan. Sequence comparison showed that the EHEC sequences are a branch of the EAST1 gene sequence family that showed the cross-species transfer in evolution among E. coli and Yersinia pestis.
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[效力级别] [学科分类] 生物化学/生物物理
[关键词] Insertion sequence;Mutation;Cross-species transfer;Enteroaggregative Escherichia coli heat-stable enterotoxin 1 gene;Enterohemorrhagic Escherichia coli;Yersinia pestis;EAST1;enteroaggregative Escherichia coli heat-stable enterotoxin 1;EAggEC;enteroaggregative Escherichia coli;EHEC;enterohemorrhagic Escherichia coli;Stx;Shiga toxin;PCR;polymerase chain reaction;PFGE;pulsed-field gel electrophoresis;IS;insertion sequence [时效性]
