α2 High molecular mass cysteine proteinase inhibitor: HMrα2‐CPI

[摘要]

HMrα₂CPI was found to be an inhibitor of human liver cathepsin H by the measurement of the dissociation constant (K _i), the association rate constant (k ₁) and the dissociation rate constant (k ₋₁) between the enzyme and the inhibitor. These data suggest that this protein-proteinase inhibitor can play a physiological role in the regulation of free cathepsin H.

[学科分类] 生物化学/生物物理

[关键词] α2-Cysteine proteinase inhibitor;Cathepsin H;Kinetic study;Physiological role;HMrα2CPI;α2 cysteine proteinase inhibitor;high-M r;C.H;cathepsin H (EC 3.4.22.16);BzArgNNap;N-benzoyl-DL-arginine-2-naphthylamide hydrochloride;ArgNNap;L-arginine-2-naphthylamide hydrochloride;LeuNNap;L-leucine-2-naphthylamide hydrochloride;ArgNMec;L-arginine-4-methyl-7-coumarylamide;E 64;L-trans-epoxysuccinyl-leucyl-amido(4-guanidino)butane;pI;isoelectric point;DTT;1;4-dithioerythreitol