Treatment of rats or liver homogenates with catecholamines (isoproterenol or noradrenaline) increased activities of both NAD+-dependent isocitrate dehydrogenase and NAD(P)+ -transhydrogenase (in the direction of hydrogen transfer NADPH → NAD+ with no change in NADP+ -dependent isocitrate dehydrogenase. These effects were realized via β-adrenoceptors. Cyclic AMP mimicked the catecholamine action on incubation with liver homogenate. The effects of catecholamines and cyclic AMP were not additive.
