The primary structure of ratfish insulin reveals an unusual mode of proinsulin processing
[摘要] The primary structure of insulin from the Holocephalan fish, Hydrolagus colliei (the ratfish), has been established by automated Edman degradation as:
[发布日期] [发布机构]
[效力级别] [学科分类] 生物化学/生物物理
[关键词] The presence of a COOH-terminal extension to the B-chain is consistent with the occurrence of a single base mutation in the region of the gene encoding one of the dibasic residue processing sites [Arg331(AGA) → Ile∗(AUA)] with the result that the ratfish has utilised an alternative cleavage site within the C-peptide region of proinsulin.;(Ratfish pancreas) Holocephalan Insulin C-peptide HPLC [时效性]
