Intracellular Ca2+‐calmodulin system involved in the palytoxin‐induced K+ release from rabbit erythrocytes

[摘要]

Palytoxin (PTX) caused K⁺ release from rabbit erythrocytes which was dependent on the concentrations of extracellular Ca²⁺ and PTX. In a Ca²⁺-free solution, PTX still caused a slow K⁺ release. An intracellular Ca²⁺ antagonist, TMB-8, an intracellular Ca²⁺ chelator, quin 2, and calmodulin inhibitors, prenylamine, W-7 and W-5, inhibited the PTX-induced K⁺ release in a Ca²⁺-free solution. These results suggest that the PTX-induced K⁺ release is dependent on the process including intracellular Ca²⁺ and calmodulin.

[学科分类] 生物化学/生物物理

[关键词] Palytoxin K+ release Ca2+ Calmodulin