Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4‐phosphate in intact human platelets

[摘要]

The present study investigates the effect of compounds that are known to elevate cAMP on the phospholipid metabolism of platelets. Prostaglandin E₁, forskolin and isobutylmethylxanthine induce an increase in [³²P]-phosphatidylinositol 4-phosphate (PIP) in platelets prelabelled with [³²P]orthophosphate. Possible roles of this phenomenon are discussed in view of the inhibitory effect of cAMP elevation on platelet activation.

[学科分类] 生物化学/生物物理

[关键词] Polyphosphoinositide Prostaglandin E1;Forskolin Isobutylmethylxanthine Platelet