The role of apoptotic and necrotic processes in cytolysis mediated by LAK cells with different phenotypes

[摘要]

The role of necrotic and apoptotic pathways in cytolysis mediated by LAK cells was studied. The contribution of necrotic and apoptotic processes to cytolysis depends both on the LAK cells' phenotype and the type of target cells. CD16+/CD8+/CD− LAK cells induced necrosis of K562 and L929 target cells. The cell death induced by CD3+/CD8+/CD1− LAK cells was found to include features of apoptotic and necrotic processes.

[学科分类] 生物化学/生物物理

[关键词] LAK cell;Apoptosis;Necrosis;LAK cells;lymphokine-activated killer cells;IL-2;interleukin-2;NK;natural killer cells;CTL;cytotoxic T-lymphocytes;TNF;tumor necrosis factor