How is rat liver S‐adenosylmethionine synthetase regulated?

[摘要]

The in vivo regulation of S-adenosylmethionine synthetase, a key enzyme in methionine metabolism, is so far unknown. The enzyme activity has been shown to be modulated by glutathione and the oxidation state of its sulfhydryl groups. Analysis of the protein sequence has revealed the presence of putative phosphorylation sites. A mixed regulatory mechanism combining phosphorylation and the oxido/reduction of sulfhydryl groups is proposed. The role of glutathione in this mechanism is also discussed.

[学科分类] 生物化学/生物物理

[关键词] S-Adenosylmethionine;Glutathione;Sulfhydryl group;Phosphorylation;AdoMet;S-adenosyl-l-methionine;AdoHcy;S-adenosyl-l-homocysteine;AdoMet synthetase;S-adenosyl-l-methionine synthetase;GSH;glutathione reduced form;GSSG;glutathione oxidized form;PK-A;protein kinase cAMP dependent;PK-C;protein kinase Ca2+ phospholipid dependent;CK-II;casein kinase II