The membrane insertion of colicins

[摘要]

Pore-forming toxins, such as colicin A, are water-soluble proteins that insert into lipid bilayers. The water-soluble structure of Colicin A is known at a high resolution and this review describes the kinetic and structural steps involved in its soluble-to-membrane bound transformation.

[学科分类] 生物化学/生物物理

[关键词] Colicin;Membrane insertion;Brominated lipid;Molten globule;Fluorescence energy transfer;Pore formation;CMC;critical micelle concentration;PD;electrical potential difference;IAEDANS;N′-(iodoacetyl)-N′-(5-sulfo-1-napthyl)-ethylenediamine