Intracellular signal transduction pathways that control pancreatic β‐cell proliferation

[摘要]

This review focuses on the factors that regulate the proliferation of pancreatic islet β-cells in vitro, and in particular on the intracellular pathways that convey the mitogenic signal into a proliferative response. Substances as diverse as nutrients, polypeptides, cytokines, adrenergic agents, lithium, phorbol esters and cyclic AMP analogs are all able to stimulate or inhibit β-cell proliferation in a time- and concentration-dependent manner. The evidence for involvement of cyclic AMP, cyclic GMP, protein kinase C, inositol polyphosphates, GTP-binding proteins, polyamines and oncogenes is reviewed.

[学科分类] 生物化学/生物物理

[关键词] Pancreatic islet;Insulin secretion;Protein kinase C;Cyclic nucleotide;Polyamine;N-protein;Cyclic AMP;adenosine-3′;5′-cyclic monophosphate;cyclic GMP;guanosine-3′;5′-cyclic monophosphate;DBI;diazepam binding inhibitor;DNA;deoxyribonucleic acid;GABA;γ-aminobutyric acid;GH;growth;hormone;GTP;guanosine trisphosphate;IGF-I;insulin-like growth factor I;PDGF;platelet-derived growth factor;Sp-cAMP[S];stimulatory diastereomer of adenosine-3′;5′-cyclic monophosphorothioate;TGF-β;transforming growth factor β;TPA;12-O-tetradecanoylphorbol 13-acetate