Oligosaccharide‐binding molecules on the surface of human hemopoietic and lymphoid cells

[摘要]

High oligosaccharide specificity for binding carbohydrate probes (biotinylated polyacrylamide with carbohydrates attached) with human hemopoietic and lymphoid cells is shown. Of 15 probes studied those bearing blood group trisaccharides, A and B, bound most intensely. In addition, transformed (leukemic and lymphoid) cells interacted more strongly than normal ones.

[学科分类] 生物化学/生物物理

[关键词] Lectin;Endogenous;Oligosaccharide probe;Malignancy;Leukocyte—endothelial cell adhesion molecule;Blood group;PAA;polyacrylamide;DMF;dimethylformamide;PBS;phosphate buffered saline;LECAM;leukocyte—endothelial cell adhesion molecules