Bradykinin degradation pathways in human blood plasma

[摘要]

The kinetics of proteolysis of bradykinin and its metabolites in human blood plasma was studied, the limiting stages were determined and each stage of the degradation was correlated with the appropriate plasma enzyme. A scheme of the pathways of major and minor degradation processes has been proposed.

[学科分类] 生物化学/生物物理

[关键词] Blood plasma;Bradykinin;Mass spectrometry;BK;bradykinin;(l-j)BK;fragment of the BK sequence from l to j amino acid residues;SIE AP;soluble ions extraction at atmospheric pressure;ACE;angiotensin-l-converting enzyme