The amiloride sensitive Na+/H+ antiport in guinea pig pancreatic acini

[摘要]

Amiloride and analogs decrease the initial rate of ²²Na⁺ uptake by dispersed acini from guineapig pancreas in a dose-dependent manner. The initial rate of amiloride-sensitive ²²Na⁺ uptake depends on external Na⁺ and H⁺ concentrations and on internal pH. These results provide evidence for the existence of a Na⁺H⁺ antiport in pancreatic acinar cells. Caerulein, a cholecystokinin analog, stimulates the activity of the Na⁺/H⁺ antiport.

[学科分类] 生物化学/生物物理

[关键词] Pancreatic acini Amiloride Na+/H+ antiport Na+ influx Intracellular pH Caerulein