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A study on the human mitochondrial RNA polymerase activity points to existence of a transcription factor B‐like protein
[摘要]

In the present work, the RNA polymerase activity of the human mitochondrial RNA polymerase mature protein (h-mtRPOLm) is shown, and its molecular activity calculated (2.1±0.9 min−1). An activity analysis of h-mtRPOLm and deleted versions of it has demonstrated that the entire recombinant protein is required for this activity. In addition, h-mtRPOLm alone or in presence of the known mitochondrial transcription factors (human mitochondrial transcription factor A and/or human mitochondrial transcription termination factor) is not able to initiate transcription from the specific human mitochondrial promoters pointing to the existence of a human mitochondrial transcription factor B-like protein.

[发布日期]  [发布机构] 
[效力级别]  [学科分类] 生物化学/生物物理
[关键词] Mitochondrial transcription;Mitochondrial RNA polymerase;Mitochondrial transcription factor A;Mitochondrial transcription factor B;Mitochondrial transcription termination factor;h-mtRPOL;human mitochondrial RNA polymerase;h-mtTFA;human mitochondrial transcription factor A;h-mtTFB;human mitochondrial transcription factor B;h-mTERF;human mitochondrial transcription termination factor [时效性] 
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