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A new FACIT of the collagen family: COL21A1
[摘要]

Interrogation of the Human Genome data for sequences related to the von Willebrand factor A-domain module identified a previously unreported 4.1 kb full-length cDNA that is predicted to encode a new member of the collagen superfamily of extracellular matrix proteins, collagen XXI. The domain organization of collagen XXI comprised an N-terminal signal sequence, followed by single von Willebrand factor A-domain and thrombospondin domains, and an interrupted collagen triple helix. The organization of these motifs predict that collagen XXI is a new member of the FACIT collagen sub-family. Expression analysis indicated that COL21A1 mRNA is present in many tissues including heart, stomach, kidney, skeletal muscle and placenta, and radiation hybrid mapping localized the COL21A1 gene to 6p11-12.

[发布日期]  [发布机构] 
[效力级别]  [学科分类] 生物化学/生物物理
[关键词] Fibril-associated collagen with interrupted triple helices;von Willebrand factor A-domain;Thrombospondin repeat;Interrupted collagen triple helix;Extracellular matrix;FACIT;fibril-associated collagen with interrupted triple helices;ECM;extracellular matrix;VA;von Willebrand factor A-domain;TN;thrombospondin domain;COL;collagenous domain;NC;non-collagenous domain;MTE;multiple tissue expression;PCR;polymerase chain reaction [时效性] 
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