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Effect of D609 on phosphatidylcholine metabolism in the nuclei of LA‐N‐1 neuroblastoma cells: a key role for diacylglycerol
[摘要]

In our previous studies, TPA treatment of LA-N-1 cells stimulated the production of diacylglycerol in nuclei, probably through the activation of a phospholipase C. Stimulation of the synthesis of nuclear phosphatidylcholine by the activation of CTP:phosphocholine cytidylyltransferase was also observed. The present data show that both effects were inhibited by the pretreatment of the cells with D609, a selective phosphatidylcholine-phospholipase C inhibitor, indicating that the diacylglycerol produced through the hydrolysis of phosphatidylcholine in the nuclei is reutilized for the synthesis of nuclear phosphatidylcholine and is required for the activation of CTP:phosphocholine cytidylyltransferase.

[发布日期]  [发布机构] 
[效力级别]  [学科分类] 生物化学/生物物理
[关键词] Phospholipase C;Diacylglycerol;D609 (tricyclodecan-9-yl xanthogenate);LA-N-1 nuclei;CTP:phosphocholine cytidylyltransferase;Phosphatidylcholine cycle;PLC;phospholipase C;PLD;phospholipase D;PtdCho;phosphatidylcholine;PtdEtOH;phosphatidylethanol;PtdIns;phosphatidylinositol;CCT;CTP:phosphocholine cytidylyltransferase;DAG;diacylglycerol;TPA;12-O-tetradecanoylphorbol-13-acetate [时效性] 
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