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Down‐regulation of N‐myristoyl transferase expression in human T‐cell line CEM by human immunodeficiency virus type‐1 infection
[摘要]

The present study focuses on the expression level of N-myristoyl transferase (NMT) in the course of human immunodeficiency virus type-1 (HIV-1) infection. HIV-1 structural proteins were gradually expressed during the process of infection of the human T-cell line CEM, whereas the expression levels of NMT subsequently decreased under the same conditions. In addition, the chronically HIV-1-infected T-cell line CEM/LAV-1 exhibited low expression levels of NMT. We hypothesize that the decrease in the expression level of NMT due to HIV-1 infection may be related to the virus’ strategy that leads to its persistent replication.

[发布日期]  [发布机构] 
[效力级别]  [学科分类] 生物化学/生物物理
[关键词] N-Myristoyl transferase;Myristoylation;Human immunodeficiency virus type-1;HIV-1;human immunodeficiency virus type-1;hNMT;human N-myristoyl transferase;mAb;monoclonal antibody;MAP;multiple antigen peptide;ELISA;enzyme-linked immunosorbent assay;p.i.;post-infection [时效性] 
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