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Accelerated telomere shortening in Fanconi anemia fibroblasts – a longitudinal study
[摘要]

Fanconi anemia (FA) is a fatal inherited disease displaying chromosomal instability, disturbances in oxygen metabolism and a high burden of intracellular radical oxygen species. Oxygen radicals can damage DNA including telomeric regions. Insufficient repair results in single strand breaks that can induce accelerated telomere shortening. In a longitudinal study we demonstrate that telomeric DNA is continuously lost at a higher rate in FA fibroblasts compared to healthy controls. Furthermore, we show that this loss is caused rather by an increased shortening per cell division in regularly replicating cells than by apoptosis.

[发布日期]  [发布机构] 
[效力级别]  [学科分类] 生物化学/生物物理
[关键词] Fanconi anemia;Telomere shortening;Fibroblast;Cell culture;FA;Fanconi anemia;ROS;reactive oxygen species;PBMC;peripheral blood mononuclear cells;PD;population doubling;TRAP;telomere repeat amplification protocol [时效性] 
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