[摘要] Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物化学/生物物理
[关键词] Antisense oligonucleotide;DNA affinity modification;(pN)16;oligonucleotide d(pTGACCCTCTTCCCATT);5'Hem(pN)16 and 3'Hem(pN)16;oligonucleotide (pN)16 bearing hemin residue at the 5'- and at the 3'-end;respectively;5'DHem(pN)16 and 3'DHem(pN)16;similar derivatives bearing the deuterohemin group [时效性]
