Time‐dependent inhibition of porcine kidney trehalase by aminosugars

[摘要]

The inhibitory effects of various nitrogen-containing sugars on porcine kidney trehalase were studied. Validamycin A, validoxylamine A and MDL 25637 were found to be potent, time-dependent inhibitors of the enzyme in vitro. The validoxylamine A-inhibited enzyme showed slow but reversible reactivation over time (t = 1.2 h). To our knowledge, this is the first report of time-dependent inhibition exhibited by either these particular amino-sugars or a trehalase.

[学科分类] 生物化学/生物物理

[关键词] Trehalase;Amino sugar;Enzyme inhibition;(Porcine kidney)