Palladium(II)‐coproporphyrin I as a photoactivable group in sequence‐specific modification of nucleic acids by oligonucleotide derivatives

[摘要]

The 34-mer oligodeoxynucleotide was shown to be selectively modified at the G17 position upon photoirradiation in the presence of complementary 17-mer oligodeoxynucleotide bearing Pd(II)-coproporphyrin I covalently linked to the 5'-end phosphate group.

[学科分类] 生物化学/生物物理

[关键词] Sequence-specific modification;Pd(II)-coproporphyrin I;Photoirradiation;Por (COOH)4;palladium (II)-coproporphyrin I;CMC;N-cyclohexyl-N'-morpholinoethyl carbodiimide metho-p-toluenesulfonate;DMF;dimethylformamide;DMSO;dimethylsulfoxide;DMAP;4-dimethylaminopyridine