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High mobility group proteins 1 and 2 bind preferentially to brominated poly(dG‐dC)·poly(dG‐dC) in the Z‐DNA conformation but not to other types of Z‐DNA
[摘要]

Three proteins from bull testis, previously thought to be Z-DNA-binding proteins but recently found to recognize brominated poly(dG-dC)·poly(dG-dC) by criteria different from the Z-conformation, were partially sequenced. Of these, the 31 kDa protein was identified as a member of the high mobility group 2 protein family, and the 33 kDa protein as a member of the high mobility group 1 protein family. Both proteins had molecular weights approximately 30% higher than expected, indicating considerable posttranslational modification. In contrast, the 58 kDa protein remained unidentified for lack of any significant homology with known protein sequences.

[发布日期]  [发布机构] 
[效力级别]  [学科分类] 生物化学/生物物理
[关键词] Z-DNA;Z-DNA-binding protein;High mobility group protein [时效性] 
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