Cobalamin inactivation induces formyltetrahydrofolate synthetase

[摘要]

Loss of cobalamin function produces profound changes in the metabolism of formate. There is impaired synthesis of formyltetrahydropteroylglutamate synthetase (CHO-H₄,PteGlu), accumulation of endogenous formate and impaired utilization of [^14C]formate. There are contradictory reports on the effect of cobalamin inactivation on CHO-H₄PteGlu synthetase. This study confirms a significant increase in synthetase activity following cobalamin inactivation.

[学科分类] 生物化学/生物物理

[关键词] Cobalamin;Formate metabolism;Formyltetrahydrofolate synthetase;Cbl;cobalamin;CHO-H4PteGlu;formyltetrahydropteroylglutamate synthetase;MTA;5′-methylthioadenosine;N2O;nitrous oxide