Revised structure of the peptide lactone antibiotic, TL‐119 and/or A‐3302‐B

[摘要]

The peptide lactone antibiotic TL-119 and/or A-3302-B was chemically synthesized in order to confirm the proposed structure. The synthetic compound was different from both natural TL-119 and A-3302-B in their physicochemical properties and in biological activity. Re-examination of the configuration of the constituent amino acid residues in natural TL-119 and/or A-3302-B indicated that natural TL-119 and A-3302-B contains D-aThr instead of the original L-Thr. We tentatively propose a revised structure for TL-119 and/or A-3302-B.

[学科分类] 生物化学/生物物理

[关键词] Cyclic peptide;Peptide synthesis;Antibacterial activity;Structure confirmation;Abbreviations used are according to IUPAC-IUB Commissions (1984) Eur. J. Biochem. 138;9-37. Other abbreviations: DCC;dicyclohexylcarbodiimide;HOBt;1-hydroxybenzotriazole;HOSu;N-hydroxysuccinimide;HPTLC;high-performance thin layer chromatography