[4,4′‐D‐Diaminopropionic acid]gramicidin S: a synthetic gramicidin S analog with antimicrobial activity against Gram‐negative bacteria

[摘要]

Gramicidin S is especially active against Gram-positive bacteria; e.g., Staphylococcus aureus. An analog, [4,4′-D-diaminopropionic acid]gramicidin S, which contains D-diaminopropionic acid residues instead of D-phenylalanine residues, has been synthesized. This analog is active against some of the Gram-negative bacteria; e.g., Escherichia coli and Salmonella typhosa. Activities of several related analogs are discussed.

[学科分类] 生物化学/生物物理

[关键词] Gramicidin S;Gram-negative bacteria;Peptide antibiotic;Peptide synthesis;Structure-activity relationship;EDC;1-ethyl-3-(3-dimethylaminopropyl) carbodiimide;HO-NSu;N-hydroxysuccinimide;TFA;trifluoroacetic acid