A new abnormal hemoglobin, Hb Kariya [α40 (C5) Lys → Glu], with an amino acid substitution at the α1β2 contact was discovered in a young Japanese man. This variant migrated to the anode faster than Hb A, being nearly the same as Hb I in electrophoretic mobility. It amounted to about 6% of the total hemoglobin of the hemolysate. This hemoglobin showed an increased oxygen affinity, decreased heme—heme interaction and a lowered 2,3-DPG effect.
