Enzymatic synthesis of a blood group A related, difucosyl heptaglycosylceramide with a type 2 carbohydrate chain

[摘要]

The presence of an α1→3 fucosyltransferase in the serum of an A₁Rh(−) Le(a−b+) Fy(a−b+) Jk(a+b+)K(−)M(−)N(+)S(−)s(+)P₁(+) human secretor was shown, capable of converting a blood group A active hexaglycosylceramide with a type 2 carbohydrate chain into the corresponding difucosyl compound under in vitro conditions.

[学科分类] 生物化学/生物物理

[关键词] Glycolipid;Fucolipid;Blood group A;Glycosyltransferase;Fucosyltransferase;GDP-fucose