Edema in the Nephrotic Syndrome: New Aspect of an Old Enigma

[摘要] The cause of edema formation in the nephrotic syndrome has been an area of intense interest by nephrologists for decades. Klisicet al.(1) in this issue of JASN have added an interesting and important new finding to the complexity of our understanding of the nephrotic syndrome. They demonstrate that apical albumin directly stimulates NHE3 (sodium hydrogen exchanger 3), the major apical transporter responsible for proximal tubule sodium reabsorption.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome