Role of PDZ Domain-Containing Proteins and ERM Proteins in Regulation of Renal Function and Dysfunction

[摘要] Hormonal, dietary, and metabolic factors play an important role in regulation of renal proximal tubular apical membrane sodium-hydrogen (Na/H) exchange and sodium-phosphate (Na/Pi) cotransport and basolateral membrane sodium-potassium-ATPase (Na-K-ATPase) activity by diverse cellular mechanisms including transcriptional, translational, and posttranslational mechanisms. Recent work in this area indicates novel protein interactions that play an important role in the fine regulation of these important physiologic processes.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome