Human Models to Evaluate Urinary Biomarkers of Kidney Injury

[摘要] It has been several years since the Board of Advisors and the Council of the American Society of Nephrology summarized a series of retreats undertaken to prioritize renal research directions given current resource limitations (1). All five working groups devoted to different areas of research in nephrology highlighted the importance of biomarker development, but two groups—acute renal failure and transplantation—went so far as to recommend the establishment of dedicated biomarker cores to speed up the processes necessary for biomarker discovery and validation. A recurring theme in the nephrology literature is that current clinical indicators of kidney injury (serum creatinine and GFR) are inadequate for timely diagnosis and prognosis, which has severely limited nephrologists' ability to reduce morbidity and mortality further in our patient populations. Supplementing current measures of renal function with well-developed kidney injury biomarkers may ultimately be the key to addressing this demoralizing problem.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome