Transplantation of the Type 1 Diabetic Patient: The Long-Term Benefit of a Functioning Pancreas Allograft

[摘要] Although simultaneous pancreas-kidney transplantation (SPK) is generally believed to be the treatment of choice in type 1 diabetic patients with kidney failure, there is continuing controversy whether SPK is superior to kidney transplantation alone (KTA), especially when a live donor kidney (LDK) is available. This controversy is highlighted by three recent publications authored by Young et al. (1), Weiss et al. (2), and our group (3). Analyzing data from large registries, all three studies compared kidney graft and patient survival in SPK (all from deceased organ donors) and KTA transplants, whereby the KTA grafts were from deceased (DDK) or living donors (LDK). The three studies are summarized in Table 1(bold) with respect to data source, treatment modality, length of follow-up, and patient and kidney graft survival. Young et al. and Weiss et al. analyzed U.S. data based on the Organ Procurement and Transplantation Network/United Network for Organ Sharing and the Scientific Registry of Transplant Recipients, respectively.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome