Value of the New Bone Classification System for Pediatric Patients with Chronic Kidney Disease

[摘要] The 2009 clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder (CKD-MBD) issued by the global organization Kidney Disease: Improving Global Outcomes (KDIGO) (1) has adopted the previous proposal to use a new definition for the skeletal component of this disorder, namely renal osteodystrophy (2). The new definition emphasizes the usefulness of assessing not only bone turnover (T) but also mineralization (M) and volume (V), the two other key histologic descriptors of bone disease. This more complete evaluation system (TMV system) (Table 1) has been recommended in the interpretation of bone biopsies for all patients with CKD.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome