Source Matters: From Phosphorus Load to Bioavailability

[摘要] Phosphorus plays crucial roles in the development of mineral and bone disorders including secondary hyperparathyroidism and vascular calcification, which eventually result in high risk for cardiovascular events and effect on survival in patients with chronic kidney disease (CKD) (1). Such an effect of phosphorus load on survival has also been demonstrated in general populations. Contribution of phosphorus load to abnormal mineral metabolism already starts from the early stages of CKD, still without significant increase of its serum level (2,3). Such effects of phosphorus load in early stages of CKD are presumably mediated by the increase of fibroblast growth factor 23 (FGF23) secretion from the bone (3,4). Although diurnal variation in serum phosphorus including postprandial changes may also contribute to the development of mineral and bone disorders and their related outcomes, these data support the importance of controlling dietary phosphorus load as well as of its serum concentration.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome