Monitoring of CD4+CD25highIL-7Rαhigh activated T Cells in Kidney Transplant Recipients

[摘要] Background and objectives In humans, circulating CD4+CD25high T cells contain mainly regulatory T cells (Treg; FoxP3+IL-7Rαlow), but a small subset is represented by activated effector T cells (Tact; FoxP3−IL-7Rαhigh). The balance between Tact and Treg may be important after transplantation. The aim of this study was first to analyze and correlate CD4+CD25high Tact and Treg with the clinical status of kidney transplant recipients and second to study prospectively the effect of two immunosuppressive regimens on Tact/Treg during the first year after transplantation.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome