Validation Study of Oxford Classification of IgA Nephropathy: The Significance of Extracapillary Proliferation

[摘要] Background and objectives The Oxford classification of IgA nephropathy (IgAN) includes mesangial hypercellularity, endocapillary hypercellularity, segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as prognosticators. The value of extracapillary proliferation (Ex) was not addressed. Because the Oxford classification excludes patients with urinary protein <0.5 g/d and eGFR <30 ml/min per 1.73 m2 at biopsy, the significance of Ex should be confirmed by validation cohorts that include more rapidly progressive cases. We present such a study.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome