eGFR: Readjusting Its Rating

[摘要] GFR is the accepted metric for evaluating renal function but measuring it directly (mGFR) can be cumbersome, time-consuming, and costly. The constant infusion method using inulin as the filtration marker, introduced in 1934 by Richards and Smith (1), has undergone many revisions that have now made mGFR easier to perform, although not widely available (2,3). A simple, reliable, unbiased, precise, and accurate estimation of mGFR, without reliance on constant infusions or timed urinary collections, would be welcome; however, as illustrated by the extensive compendium of comparisons of mGFR (using classical inulin clearance methods) to eGFR by Botev et al. (4) in this issue of CJASN, this objective is far from being realized.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome