This Month's Highlights

[摘要] Mutations in the gene encoding α-actinin-4 cause an inherited form of FSGS. Here, Henderson et al. distinguish the histopathology of this cause of FSGS from others. They observed that FSGS resulting from α-actinin-4 mutations exhibits cytoplasmic electron-dense aggregates in podocytes. In addition, immunofluorescence using an antibody that recognizes both mutant and wild-type α-actinin-4 reveals a segmental, irregular, granular staining pattern in glomerular capillary loops compared with the global, linear pattern of other podocytopathies. See Henderson et al., pages 961–968.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome