Renal Volume in Children with ADPKD: Size Matters

[摘要] Autosomal dominant polycystic kidney disease (ADPKD) is characterized by a relatively slow increase in kidney size as a result of cyst growth and expansion (1,2). Initiated in utero, this process continues over decades before the loss of renal function. Recent data from the Consortium for Radiologic Imaging Studies in Polycystic Kidney Disease (CRISP) study indicate that kidney growth is a critical predictor of progression to renal failure in ADPKD, playing a more important role than hypertension, proteinuria, age, or gender (3). Modeling experiments using prospective clinical data from the CRISP cohort have suggested that very high rates of kidney growth must occur during childhood to account for the kidney volumes observed in adults (4).

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome