Is it AKI or Nonrecovery of Renal Function That Is Important for Long-Term Outcomes?

[摘要] Epidemiologic research examines relationships between exposures and outcomes, with the ultimate goal of improving patient outcomes. To affect a change and improve outcomes, the relationships described must not only be causal, but modifiable (1). Numerous studies have described independent associations between AKI and subsequent CKD and mortality (2). The majority of these studies focused on one dimension of AKI, “severity,” via the magnitude of peak rise in serum creatinine (2–4). Recently, some investigations have examined long-term outcomes associated with other dimensions of AKI including duration (5) and kidney function after peak (i.e., recovery) (6–8).

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome