Effects of Oral Sodium Bicarbonate in Patients with CKD

[摘要] Background and objectives Metabolic acidosis contributes to muscle breakdown in patients with CKD, but whether its treatment improves functional outcomes is unknown. The choice of dose and tolerability of high doses remain unclear. In CKD patients with mild acidosis, this study evaluated the dose–response relationship of alkali with serum bicarbonate, its side effect profile, and its effect on muscle strength.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome