Shades of Grey: The Conundrum of Implantable Defibrillators in Individuals with Advanced CKD

[摘要] CKD contributes significantly to the global health burden, with a prevalence estimated at 10%–12% of individuals worldwide (1). Morbidity and mortality rates remain high in these individuals (2–5), and they are at a particularly magnified risk of sudden cardiac death (SCD) (6,7). To wit, in a study by Pun et al. (6) of 19,440 patients with coronary artery disease undergoing cardiac catheterization, declining renal function was associated with a progressive increase in risk of SCD. Similarly, in a seminal study, Anavekar et al. (3) studied 14,527 patients with acute myocardial infarction and found an increase in risk of death because of cardiovascular etiologies and higher rates of cardiac arrest at lower eGFRs.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome