Unexpected Role of TRPC6 Channel in Familial Nephrotic Syndrome: Does It Have Clinical Implications?

[摘要] Focal and segmental glomerulosclerosis (FSGS) is a leading cause of glomerulonephritis and chronic kidney disease (CKD) in children and young adults (1). As much as one fifth of the ESRD population carries this diagnosis, and the proportion of ESRD attributed to FSGS has increased more than 10-fold over the past two decades (2). The glomerular landmarks of FSGS can develop secondary to a variety of systemic conditions, including disorders that cause chronic hypoxemia, processes that augment glomerular blood flow, and diseases that reduce renal mass. The structural features of FSGS also develop in patients who lack recognized systemic diseases, so-called primary (or idiopathic) FSGS. Over the past three decades, the recognition of familial forms of FSGS has grown, and this information has been highlighted in recent years with characterization of several human genes that cause FSGS (3).

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome