Multiple Myeloma

[摘要] Multiple myeloma is a plasma cell dyscrasia that accounts for almost 10% of all hematologic malignancies (1,2). The annual incidence of multiple myeloma is 4.3 per 100,000 people (3,4), but the incidence ranges from 1 per 100,000 for people who are 40 to 49 yr of age to 49 per 100,000 population for those who are ≥80 yr of age (5). To distinguish multiple myeloma from other plasma cell dyscrasias, the diagnosis is based on histologic, serologic, and radiographic features and includes bone marrow with clonal plasma cells or histologic confirmation of a plasmacytoma; a monoclonal protein in the serum or urine (unless the patient has a nonsecretory myeloma [3% of patients]); and end-organ damage evidenced by renal insufficiency, hypercalcemia, anemia, or lytic bone lesions (2,6). The diagnosis of myeloma often results from the workup of unexplained renal disease, and in a study of renal biopsies in elderly patients with unexplained renal failure, 40% of patients with cast nephropathy had previously undiagnosed myeloma (7).

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome