Measuring T Cell Alloreactivity to Predict Kidney Transplant Outcomes: Are We There Yet?

[摘要] Assessment of pretransplant immunological risk is a critical part of improving renal transplant outcome. By carefully determining pretransplant immunological risk assessment, it may be possible to optimize individual therapy decisions related to immunosuppression regimens, thereby improving transplant outcomes. Improving transplant outcomes would lessen the need for retransplantation, which in turn would have a positive impact on the shortage of donor organs. Furthermore, pretransplant immunological risk assessment could potentially help the transplant community make more informed decisions related to organ allocation, and that may also improve overall outcomes and alleviate organ shortages. Currently, pretransplant tests to assess transplant rejection and graft loss risk include HLA matching between donor and recipient and routine screening for panel reactive antibodies (PRA) in the recipient. At the time of transplant, a final cross-match is preformed to assess antidonor antibodies and to make a final decision on acceptance of the donor; a positive cross-match being a contraindication to transplantation between the recipient and donor pair.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome