Lithium, Cyclic AMP Signaling, A-Kinase Anchoring Proteins, and Aquaporin-2

[摘要] Largely from studies on isolated amphibian tissues—skin and urinary bladder—we know that vasopressin (AVP) exerts its antidiuretic action by making the responsive epithelium more permeable to water and urea. The nature of the membrane changes and the means by which the membrane changes are induced by the hormone remain to be elucidated. Of special interest is the finding of Orloff and Handler (1) that 3′5′ cyclic adenosine monophosphate (3′5′ cAMP), which has been implicated as an intracellular mediator of the action of several peptide hormones, mimics the action of AVP. Furthermore, increased tissue content of cAMP has been noted after exposures of responsive tissues to vasopressin (2).”

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome