Risk for Progression to ESRD: Further Evidence from Population-Based Studies

[摘要] Editors Note: The classification of degrees of renal dysfunction into stages of chronic kidney disease (CKD) and the consequent appreciation of its high prevalence, around 10% in most population studies, has transformed clinical nephrology from its traditional focus on ESRD prevalent in the late 20th century to a new and much broader approach in the early 21st century. The recognition of the striking association of CKD with cardiovascular disease has made the issue of CKD even more important from a public health perspective. However, although the basic facts are now well established, there remain many important and unanswered questions that have major implications for the numbers we use to discuss the ′epidemic′ of CKD and for the consequent impact on public policy. These uncertainties range from issues of exactly how renal function should best be measured to rather wide variations in incidence, prevalence, and prognostic data among different racial populations and regions, all of which likely provide clues to underlying biologic mechanisms.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome