Corticosteroids and Kidney Transplantation

[摘要] The Karolinska Institute awarded Dr. Philip Hench a Nobel Prize in the 1950s for treating a patient who had rheumatoid arthritis with corticosteroids. In the 1950s, physicians saw corticosteroids as “miracle drugs” that offered dramatic relief for a diverse group of diseases. Physicians saw extraordinary benefits, such as rheumatoid arthritis patients’ throwing away their crutches or resolution of anaphylactic reactions. The medical community was delighted. The euphoria resulted in the uncritical use of these new agents. However, before long, the medical profession saw the downside of corticosteroid therapy with its diverse chronic toxicities. This two-edged sword has had an impact on solid-organ transplantation from its start in the 1960s until the present day.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome